Thirteen teams have now qualified for the last 32 including Bayer Leverkusen, FC Zurich and Lazio who had already secured places in the next stage of the competition.
Manchester United's season, already their worst in the Premier League, hit a new low with their 1-0 defeat to Spurs in that final in Bilbao that denied them a spot in this season's Champions League.
Managerless Tottenham Hotspur face a long trip to Ukraine for a meeting with former boss Juande Ramos after being drawn against Dnipro Dnipropetrovsk in the last 32 of the Europa League.
Liverpool handed their fiercest rivals a painful lesson on Thursday with a dominant 2-0 win over Manchester United in the first leg of a Europa League last-16 clash.
Man United boss Amorim says he has no plans to quit
Bilbao condemn fans behaviour in Europa League match at Roma
Goals from Jan Vertonghen and Jermain Defoe left Tottenham Hotspur on the cusp of the Europa League knockout stages as four other clubs maintained perfect starts on Thursday.
Borussia Dortmund snatched a late goal at Atalanta to progress with a 1-1 draw, while AC Milan and Atletico Madrid, both with three-goal leads from the away legs, completed the formality of qualifying with 1-0 wins at home on Thursday.
Europa League favourites Manchester United secured a 1-1 draw on a threadbare pitch at Rostov, while Olympique Lyonnais beat AS Roma 4-2 helped by a fine individual goal from Nabil Fekir in their last 16, first leg ties on Thursday.
Four-time European Champions Ajax Amsterdam were felled at the first hurdle of the continent's second tier Europa League on Thursday, exiting in the group stage two days after rivals PSV Eindhoven celebrated long-awaited success.
'Players like Marcus Rashford and Jesse Lingard -- they've been brought up in this city. Paul Pogba was brought up in the city from the age of 14. They will find if difficult'
Holders Sevilla maintained their Europa League challenge with a 1-0 win over Rijeka in a winner-takes-all clash on Thursday.
New Liverpool boss Juergen Klopp made it three wins from his last three matches with a 1-0 success at Rubin Kazan in Russia that left them second in Group B, two points behind Swiss club Sion on Thursday.
A player in Sevilla's first team squad has tested positive for COVID-19 ahead of their Europa League last-16 tie against AS Roma, the La Liga club announced on Wednesday. The Spanish club said they conducted tests on Sunday on players, coaches and staff. The player, who was not named, is asymptomatic and is self-isolating at home.
Bruno Fernandes milestone and late drama lift Manchester United past Chelsea with a chaotic 2-1 win over Chelsea at Old Trafford
Arsenal teenager Bukayo Saka scored his first goal for the club as they beat 10-man Eintracht Frankfurt 3-0, while Manchester United's 17-year-old Mason Greenwood secured a 1-0 win over FC Astana as the Europa League group stage began on Thursday.
News of all that's transpired on and off the football field
Manchester United took a big step towards the Europa League quarter-finals by thrashing Austrian side LASK Linz 5-0 on Thursday in their last 16 first-leg tie at an empty Linzer Stadium due to the coronavirus pandemic.
Red Star, who won the European Cup in 1991 and reached the latter stages the following season, finished second in Group H behind Arsenal who crushed BATE Borisov 6-0.
On Sunday the Ukrainian Tennis Federation urged the sport's governing body the International Tennis Federation (ITF) to immediately expel Russia and Belarus from the organisation and ban Russia from team and individual tournaments. Also, athletes from Ukraine and other nations have called on the International Olympic Committee (IOC) to suspend Russia and Belarus and ban their athletes from events immediately.
European football was given good and bad reminders of its past on Thursday with an impressive 2-0 win for once-mighty Ajax Amsterdam over Schalke 04 in one Europa League game but ugly scenes in the crowd at Lyon delaying another.
Manchester City and Chelsea both secured their Champions League places with victories on the final day of the English Premier League season and Newcastle United joined them despite stumbling to a last-day defeat.
IMAGES from the Europa League matches played on Thursday
Liverpool have signed French striker Hugo Ekitike from Eintracht Frankfurt, the English Premier League side announced on Wednesday.
Rattled by embarrassing domestic defeats, Chelsea looked jittery before Olivier Giroud settled their nerves with a close range tap-in shortly after halftime at StamfordBridge following good work by N'Golo Kante and Willian in the build-up.
Liverpool shrugged off the absence of Mohamed Salah as midfielder Dominik Szoboszlai scored an 88th-minute penalty to give them a 1-0 Champions League win at Inter Milan.
News of all that's transpired on and off the football field
West Ham United marked their first match at the Olympic Stadium with a 3-0 win over Slovenian side NK Domzale, Cheikhou Kouyate scoring twice to help secure a place in the Europa League playoff round.
Xabi Alonso has signed a three-year contract until June 2028 and the 43-year-old replaces Carlo Ancelotti, who took charge of his last game on Saturday.
>Manchester United's star centre-back Harry Maguire was spotted in Mumbai on Thursday, May 29, 2025, exploring the local food scene and connecting with the community.
A round-up of Tuesday's action in the UEFA Champions League.
The move came after Manchester-born Rashford, who made 426 senior appearances and scored 138 goals for United in all competitions, fell out of favour with manager Ruben Amorim.
Thomas Frank will take charge of a club that will take part in next year's Champions League after they won the Europa League last month in Bilbao.
Schalke 04 hit back from two goals down to draw 2-2 and overcome fellow Germans Borussia Moenchenglach on away goals in their Europa League last 16 tie while Manchester United edged Rostov 1-0 to progress on Thursday.
United climbed to fourth in the standings on 15 points going into the last round of matches, in a strong position to reach the knockout phase along with Spurs who are sixth with 14 points.
Rasmus Hojlund scored an equaliser deep into stoppage time as Manchester United salvaged a 1-1 away draw at 10-man Bournemouth in the Premier League on Sunday.
Liverpool roared back from a goal behind to thrash Tottenham Hotspur 5-1 and wrap up the English Premier League title in style.
Francisco Moura's second-half strike earned hosts Porto a 1-1 draw against 10-man AS Roma in the first leg of their Europa League knockout round play-off on Thursday.
Mourinho was hired as manager and technical director in June as Fenerbahce chase their first Turkish league title since 2014. He was attempting to get his new team into the revamped 36-team league stage of the Champions League, which he won with Porto in 2004 and Inter Milan in 2010.
Real Madrid will play local rivals Atletico Madrid while Bayern Munich were drawn against Bundesliga title challengers Bayer Leverkusen on Friday.